Repellent Evidence Database: What Works, Safety & Sources

A practical reference for choosing pest-control and repellent methods based on government and university-extension guidance. It separates well-supported methods from promising or poorly supported claims and highlights the safety conditions that matter.

Last evidence review: July 30, 2026. This database is educational, not medical, veterinary, or pesticide-label advice. Always follow the product label and local regulations.

How we rate evidence

  • Strong: directly recommended or evaluated by a government public-health, pesticide-regulation, or university IPM source.
  • Moderate: supported as part of a broader control program, with important limits or variable results.
  • Limited/uncertain: evidence is inconsistent, the product is not evaluated for effectiveness, or claims exceed the cited source.
Pest / goal Method Evidence What the evidence supports Safety / limitations Primary guidance
Mosquito bites EPA-registered skin repellent containing DEET, picaridin, IR3535, OLE/PMD, or 2-undecanone Strong CDC recommends EPA-registered repellents with these active ingredients to prevent bites. Follow the label. Do not use OLE/PMD on children under 3. “Pure” lemon eucalyptus essential oil is not the same as registered OLE repellent. CDC; EPA
Mosquitoes around the home Weekly container-water removal plus repaired screens Strong Reducing standing water removes egg-laying sites; screens reduce indoor entry. Requires repeated inspection after rain; it reduces breeding and entry but does not create complete protection. CDC
Ticks on people 0.5% permethrin-treated clothing and gear Strong CDC recommends treated boots, clothing, and gear as part of tick-bite prevention. Do not apply permethrin products directly to skin. Follow treatment and laundering directions. CDC; CDC permethrin guide
Bed bugs Integrated pest management: identification, preparation, monitoring, nonchemical and labeled chemical tools Strong EPA says combining methods is generally more effective than relying on one treatment. There is no instant fix. Foggers and illegal treatments can cause harm; professional help is often appropriate. EPA
Bed bugs in washable items High-heat clothes dryer as one IPM component Moderate EPA includes high-temperature drying among useful nonchemical controls. Heat must reach the required level and duration; washing alone is not reliable. Whole-room heat should be professionally managed. EPA
Cockroaches Food/water removal, monitoring traps, and precisely placed enclosed baits Strong University IPM guidance supports sanitation, monitoring, and baits placed where activity is found. Baits act slowly. Keep products inaccessible to children and pets and do not contaminate bait with repellent sprays. University of Minnesota Extension
Cockroaches Boric acid dust in isolated cracks/voids as a bait supplement Moderate Extension guidance lists boric acid dust as a supplement to bait-based control. Not a general surface powder. Apply only where the label permits and where children and pets cannot reach it. University of Minnesota Extension
Household ants Identify species, remove food/water, seal entry points, then use enclosed bait if needed Strong IPM targets the conditions supporting the colony and uses lower-risk tools before repeated spraying. The wrong bait or pesticide may add risk without controlling the species. Keep baits inaccessible. Penn State Extension
Mice and rats Seal gaps, remove accessible food, use snap traps, and clean contamination safely Strong CDC’s prevention framework is “Seal Up, Trap Up, Clean Up.” Rodent droppings and urine can spread disease. Use CDC cleanup guidance rather than sweeping or vacuuming dry contamination. CDC
Mice and rats Consumer rodenticide only in the supplied tamper-resistant bait station Strong safety requirement EPA requires consumer products to secure block or paste bait within approved stations. Poison can harm children, pets, and wildlife directly or through poisoned rodents. Trapping and exclusion may be preferable. EPA
Fleas and ticks on pets Species- and weight-specific labeled product selected with veterinary advice Strong EPA advises consulting a veterinarian and using only products labeled for the animal species, age, and weight. Never use a dog-only product on a cat. Monitor for reactions and retain the package. EPA
Deer browsing Physical barriers or small fenced exclosures around valuable plants Moderate Extension guidance identifies physical barriers as a practical control measure, particularly around high-value plants. Design and height must match the site and deer pressure. Repellent sprays require diligent reapplication and results vary. University of Minnesota Extension
“Natural” mosquito or tick repellents Unregistered essential-oil mixtures Limited / uncertain CDC says the effectiveness of non-EPA-registered repellents is not known; registered OLE/PMD products should not be confused with pure essential oils. “Natural” does not establish effectiveness or safety. For disease-vector protection, choose an EPA-registered repellent. CDC; CDC Yellow Book

How to use this database

  1. Identify the pest before selecting a treatment.
  2. Start with prevention, exclusion, sanitation, and monitoring.
  3. If a pesticide is necessary, verify the exact pest and application site on the label.
  4. Reassess results instead of repeatedly adding products.
  5. Use a licensed professional when identification, infestation size, structural treatment, or safety risk exceeds a DIY approach.

Editorial standard

Entries are based on linked primary guidance and are reviewed for the specific claim shown—not for every possible use of a product. Commercial brands are intentionally omitted. We will expand this page as additional methods are checked against current sources.

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